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Highways for mRNA Transport

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Presentation on theme: "Highways for mRNA Transport"— Presentation transcript:

1 Highways for mRNA Transport
Robert H. Singer  Cell  Volume 134, Issue 5, Pages (September 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Conserved Mechanisms for mRNA Localization in Oocytes
Microtubules are oriented in both directions in oocytes from the fruit fly Drosophila (upper left) and the frog Xenopus (upper right). Dual polarity of microtubules is a feature of neuronal dendrites as well. In such cases, granules containing mRNAs (turquoise) can move in either direction, but the predominant orientation of the microtubules determines the overall directional bias (see expanded view). In cases where the microtubule orientation that promotes the eventual mRNA localization is in the minority, an anchoring mechanism must remove mRNAs from the mobile pool. Several kinesins are responsible for this plus-end-directed movement (shown in pink and gold). It is likely that this anchoring mechanism (indicated by anchor icon) includes cortical actin (shown as filaments) and may also include Tropomyosin and Staufen. Translation then occurs after anchoring (ribosomes indicated). Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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