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Volume 3, Issue 3, Pages (May 2017)

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Presentation on theme: "Volume 3, Issue 3, Pages (May 2017)"— Presentation transcript:

1 Volume 3, Issue 3, Pages 236-239 (May 2017)
Methotrexate-induced cutaneous ulceration in 3 nonpsoriatic patients: Report of a rare side effect  Hal A. Lewis, BS, Kathleen M. Nemer, MD, Rebecca J. Chibnall, MD, Amy C. Musiek, MD  JAAD Case Reports  Volume 3, Issue 3, Pages (May 2017) DOI: /j.jdcr Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Superficial ulcerations with crusting and scaling on the hand, digits, arm, and shin. JAAD Case Reports 2017 3, DOI: ( /j.jdcr ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Histologic examination of a punch biopsy taken from the left forearm shows a focal subepidermal split with epidermal necrosis. (H&E; original magnifications: left, ×10 and right, ×20.) JAAD Case Reports 2017 3, DOI: ( /j.jdcr ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Histologic examination of a punch biopsy taken from the right thigh shows epidermal dysmaturation and a mixed dermal inflammatory infiltrate with eosinophils. (H&E; original magnifications: left, ×10 and right, ×20.) JAAD Case Reports 2017 3, DOI: ( /j.jdcr ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Necrotic, ulcerated nodules with surrounding erythema on the left second digit at the proximal interphalangeal joint, right knee, and left dorsal foot. JAAD Case Reports 2017 3, DOI: ( /j.jdcr ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

6 Fig 5 Histologic examination of a punch biopsy taken from the left knee shows epidermal dysmaturation with nuclear pleomorphism and atypical mitotic figures. (H&E; original magnifications: left, ×10 and right, ×20.) JAAD Case Reports 2017 3, DOI: ( /j.jdcr ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

7 Fig 6 Thin, crusted ulcerations on the medial thighs and an eroded plaque underneath the pannus. JAAD Case Reports 2017 3, DOI: ( /j.jdcr ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

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