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Big science and big data in nephrology

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Presentation on theme: "Big science and big data in nephrology"— Presentation transcript:

1 Big science and big data in nephrology
Julio Saez-Rodriguez, Markus M. Rinschen, Jürgen Floege, Rafael Kramann  Kidney International  DOI: /j.kint Copyright © 2019 International Society of Nephrology Terms and Conditions

2 Figure 1 Overview of data generation and analysis for nephrology.
Kidney International DOI: ( /j.kint ) Copyright © 2019 International Society of Nephrology Terms and Conditions

3 Figure 2 The most common omics technologies and the information they provide regarding molecular processes. scRNA, single-cell RNA; SNP, single-nucleotide polymorphism; Transc., transcription; WES, whole-exome sequencing; WGS, whole-genome sequencing. Kidney International DOI: ( /j.kint ) Copyright © 2019 International Society of Nephrology Terms and Conditions

4 Figure 3 Computational strategies to apply statistics and machine learning to big data. Use of prior knowledge to extract molecular signatures can facilitate subsequent analyses. Kidney International DOI: ( /j.kint ) Copyright © 2019 International Society of Nephrology Terms and Conditions

5 Figure 4 Timeline of technological developments and their incorporation into basic and translational research in the renal and oncology (“cancer”) fields. GWAS, Genome-Wide Association Study; KPMP, Kidney Precision Medicine Project; Nat Gen, Nature Genetics; scRNA, single-cell RNA; TCGA, The Cancer Genome Atlas. Kidney International DOI: ( /j.kint ) Copyright © 2019 International Society of Nephrology Terms and Conditions


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