1. Spatial differences in biologic activity of large uterine leiomyomata
Jian-Jun Wei, M.D., Xing-Min Zhang, M.D., Luis Chiriboga, Ph.D., Herman Yee, M.D., Ph.D, Mary A. Perle, Ph.D., Khush Mittal, M.D. 
Fertility and Sterility 
Volume 85, Issue 1, Pages (January 2006)
DOI: /j.fertnstert
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2. FIGURE 1
Scheme diagram of the tissue microarray preparation from three-dimensional tumor sections in the large uterine leiomyomata (ULM). (A) Tissue sections were dissected from 3 axes (X, Y, and Z) and 6 zones (from center to periphery). (B) H&E-stained slides from each tissue section were reviewed and tissue cores taken and arrayed on a recipient block (C). (D) Some examples of immunoreactivity for Factor VIII (F8) and VEGF in large ULM (zones 1 to 6), myometrium (MM), and small ULM (S-ULM).
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3. FIGURE 2
Differential expression of ER and PR in large (L-ULM) and small (S-ULM) ULM. (A) The levels of ER (dashed line) and PR (solid line) expression in L-ULM (from zone 1 to zone 6) and in S-ULM. The baseline of ER/PR values in myometrium (MM) is set as zero. (B) The mean scores of ER and PR in S-ULM and L-ULM. The standard errors are indicated as vertical T bars. *P<.05.
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4. FIGURE 3
Spatially differential expression of GCR and MIB1 (left panel) and CD24, EGFR, IGF1R, HMGA2, RXR, IGF2, and Bcl2 (right panel) in the large ULM (from zone 1 to zone 6) in comparison to small ULM (S-ULM). The baselines in myometrium (MM) for each marker are set as zero. The standard errors for GCR and MIB1 are given as vertical T bars. *P<.05.
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

5. FIGURE 4
Spatial distribution of the vessel density (A) and percentage of hyaline degeneration (B) in large ULM (from zone 1 to zone 6) and in small ULM (S-ULM). The baselines of the vessel density and hyalinization in myometrium (MM) are set as zero. *P<.05.
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

6. FIGURE 5
Spatially differential expression of VEGF (solid line) and HIF1 (dashed line) in the large ULM (from zone 1 to zone 6) and in small ULM (S-ULM). The baselines of VEGF and HIF1 values in myometrium (MM) are set as zero. The standard errors were given as vertical T bars. *(P<.05); **(P<.01).
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

7. FIGURE 6
Spatially differential expression of the selected gene products (listed on the right) in large uterine leiomyosarcomas (LMS) (from zone 1 to zone 6) and matched small ULM (S-ULM). The baselines for each marker value in myometrium (MM) are set as zero.
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

8. FIGURE 7
Differential expression of the gene products (indicated below the bars), vessel density, and hyaline degeneration between the large ULM (L-ULM) and small (S-ULM) ULM. The standard errors are shown as vertical T bars. *P<.05.
Wei. Spatial differences in large leiomyomata. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions