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Comparison of the antiasthmatic, oropharyngeal, and systemic glucocorticoid effects of budesonide administered through a pressurized aerosol plus spacer.

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Presentation on theme: "Comparison of the antiasthmatic, oropharyngeal, and systemic glucocorticoid effects of budesonide administered through a pressurized aerosol plus spacer."— Presentation transcript:

1 Comparison of the antiasthmatic, oropharyngeal, and systemic glucocorticoid effects of budesonide administered through a pressurized aerosol plus spacer or the Turbuhaler dry powder inhaler  John H. Toogood, MD, FRCPCa,b, Frederick A. White, MD, FRCPCa,b, Jon C. Baskerville, PhDc, Lawrence J. Fraher, PhDb,d,e, Barbara Jennings, PhDf  Journal of Allergy and Clinical Immunology  Volume 99, Issue 2, Pages (February 1997) DOI: /S (97) Copyright © 1997 Mosby, Inc. Terms and Conditions

2 FIG. 1 Group mean responses to graded doses of budesonide inhaled through Turbuhaler (triangles) or pMDI + Nebuhaler (circles) with relevant p values from ANCOVA. A, Measures of oropharyngeal or airway deposition. B, Measures of systemic glucocorticoid activity. Oropharyngeal Candida colony counts were log-transformed for analysis. Except for FEV1, the responses were dose-dependent. BL, Baseline; BUD, budesonide. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

3 FIG. 1 Group mean responses to graded doses of budesonide inhaled through Turbuhaler (triangles) or pMDI + Nebuhaler (circles) with relevant p values from ANCOVA. A, Measures of oropharyngeal or airway deposition. B, Measures of systemic glucocorticoid activity. Oropharyngeal Candida colony counts were log-transformed for analysis. Except for FEV1, the responses were dose-dependent. BL, Baseline; BUD, budesonide. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

4 FIG. 2 Ratio of overall effects of budesonide treatment, administered by Turbuhaler or pMDI + Nebuhaler, for each of eight response indices. See text for description of method of calculating response ratios. Effects of the Turbuhaler and pMDI + Nebuhaler on budesonide delivery to the oropharynx and pulmonary airways and systemic delivery appear essentially equivalent under the conditions of this study. TBH, Turbuhaler; Neb, Nebuhaler; FA, 7-day mean of frequency of asthma symptoms per day; EOS, peripheral blood eosinophil count; SC, serum cortisol; OC, serum osteocalcin; CA, oropharyngeal Candida colony count. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

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