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Sofia Gkountela, Amander T. Clark  Cell Stem Cell 

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1 A Big Surprise in the Little Zygote: The Curious Business of Losing Methylated Cytosines 
Sofia Gkountela, Amander T. Clark  Cell Stem Cell  Volume 15, Issue 4, Pages (October 2014) DOI: /j.stem Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 The Male and Female Pronucleus Each Use Three Different Mechanisms to Remove 5mC from the Genome The specific pathways required for active removal of 5mC and 5hmC from the genome remain to be determined. DNA demethylation downstream of 5hmC occurs predominantly in the paternal pronucleus mostly by a 5hmC-replication-dependent pathway. The female pronucleus mostly uses replication-dependent demethylation with a small contribution through 5hmC. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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