1. Mechanisms of diarrhea in collagenous colitis
Natalie Bürgel, Christian Bojarski, Joachim Mankertz, Martin Zeitz, Michael Fromm, Jörg–Dieter Schulzke 
Gastroenterology 
Volume 123, Issue 2, Pages (August 2002)
DOI: /gast
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2. Fig. 1
Original impedance locus plots of human sigmoid colon. (A) Control; (B) collagenous colitis. Zreal gives the ohmic component and Zimaginary the reactive component of the complex impedance. Intersections between the semicircle and x axis at low and high frequencies represent Rt and Rsub, respectively. Rt minus Rsub equals the Re. For a detailed explanation of transepithelial impedance data, see references 21–23.
Gastroenterology  , DOI: ( /gast )
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3. Fig. 2
Apoptoses in collagenous colitis. Apoptosis in a thin section of sigmoid colon is shown. Condensed chromatin fragments in nuclei and segmentation of the nuclei indicated epithelial apoptoses (arrows). (A and B) TUNEL and DAPI staining in the sigmoid colon of a control patient. (C and D) TUNEL and DAPI staining in the sigmoid colon of a patient with collagenous colitis (original magnification 20×).
Gastroenterology  , DOI: ( /gast )
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4. Fig. 3
Histology of collagenous colitis. Shown is a thin section of a biopsy specimen endoscopically obtained from the sigmoid colon of (A and B) a control and (C and D) a patient with collagenous colitis stained with (A and C) H&E and (B and D) tenascin (original magnification 20×).
Gastroenterology  , DOI: ( /gast )
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5. Fig. 4
Tight junction proteins occludin and claudin 1–5. Expression of tight junction proteins in crude membrane fractions by immunoblotting (samples with 5 μg protein). Each lane represents one biopsy. Lanes 1–3 represent samples from the sigmoid colon of controls, and lanes 4–6 represent samples from the sigmoid colon of patients with collagenous colitis. A second immunoblot was run on 2 further patients and 2 further controls (data not shown). Statistical data of densitometric analysis represent protein expression of the samples from 5 different patients with collagenous colitis (in percentage of the controls).
Gastroenterology  , DOI: ( /gast )
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6. Fig. 5
Correlation of clinical, functional, and morphologic data in collagenous colitis. (A) Inverse correlation of Re obtained by alternating impedance analysis and the degree of the diarrhea as given by the frequency of (loose) stools per day. (B) Correlation of Rsub obtained by alternating impedance analysis and the thickness of the subepithelial collagenous band. (C) No significant correlation of Re obtained by alternating impedance analysis and claudin-2 expression obtained by densitometry from Western blots could be detected (compare with Figure 4).
Gastroenterology  , DOI: ( /gast )
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