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Published byRebecca Vestergaard Modified over 5 years ago
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Ischemic postconditioning promotes left ventricular functional recovery after cardioplegic arrest in an in vivo piglet model of global ischemia reperfusion injury on cardiopulmonary bypass Gen Shinohara, MD, Kiyozo Morita, MD, PhD, Ryuichi Nagahori, MD, PhD, Yoshihiro Koh, MD, PhD, Katsushi Kinouchi, MD, Takayuki Abe, MD, Kazuhiro Hashimoto, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 142, Issue 4, Pages (October 2011) DOI: /j.jtcvs Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions
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Figure 1 Experimental protocols of the different groups. All piglets were subjected to 90 minutes of cardioplegic arrest under cardiopulmonary bypass (CPB). In the control group, there was no intervention before 30 minutes of reperfusion. The postconditioning (Post-con) groups received 6 cycles of 10 seconds (s) of reperfusion/10 seconds of ischemia (Post-con 10) or 3 cycles of 30 seconds of reperfusion/30 seconds of ischemia (Post-con 30) at the start of 30 minutes of reperfusion. Cardiac function was measured before CPB and at 30 minutes after reperfusion just after weaning from CPB. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions
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Figure 2 Ventricular function curves were created by plotting left atrial pressure (LAP) (x axis) versus left ventricular stroke work index (LVSWI) (y axis), and linear regression lines were drawn. The area of the trapezoid between the regression lines for the minimum and maximum LAP obtained before and after cardiopulmonary bypass was defined as the area under the left ventricular function curve. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions
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Figure 3 (A) End-systolic elastance (Ees), (B) time constant of isovolumic relaxation (Tau), (C) and left ventricular stroke work index (LVSWI) after 30 minutes of reperfusion. Each parameter is shown as the percent recovery from the preischemic value. Data are reported as the mean ± standard error of the mean. *P < .05, **P < .01 versus control group. There are no significant differences in Ees, Tau, and LVSWI between 2 postconditioning groups. There is not statically significant, but marginally significant, improvement of LVSWI in the postconditioning (Post-con) 10 group compared with control (P = .084). NS, Not significant. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions
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Figure 4 Changes of the plasma troponin-T levels. Post-con, Postconditioning; NS, not significant; R, reperfusion. *P < .05 versus all groups. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions
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