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Volume 140, Issue 1, Pages (January 2011)

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1 Volume 140, Issue 1, Pages 124-131 (January 2011)
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study  Christopher D. Williams, Joel Stengel, Michael I. Asike, Dawn M. Torres, Janet Shaw, Maricela Contreras, Cristy L. Landt, Stephen A. Harrison  Gastroenterology  Volume 140, Issue 1, Pages (January 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions

2 Figure 1 Patient flowchart.
Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

3 Figure 2 The prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic fatty liver disease (NASH) among the entire study cohort was 46% and 12.2%, respectively. The prevalence of NAFLD varied among different ethnic groups. The prevalence of NASH among patients identified as having fatty liver on ultrasound was 29.9%. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

4 Figure 3 Insulin and alanine aminotransferase (ALT) were found to be independently predictive of nonalcoholic fatty liver disease (NASH). Using these variables, an equation was created to predict NASH with a receiver operating characteristic of (95% CI: 0.72−0.89; P < .001). Using a cut-off value of −0.806 derived from equation, the sensitivity and specificity are approximately equal to 75%. Subsequently, a probability curve for insulin and ALT for detecting NASH was created. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

5 Figure 4 The prevalence of nonalcoholic fatty liver disease (NASH) varied among ethnic groups. Hispanics had the highest prevalence, followed by African Americans and Caucasians. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions


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