1. Volume 59, Issue 3, Pages 876-882 (March 2001)
Relaxin decreases renal interstitial fibrosis and slows progression of renal disease 
Sandra L. Garber, Yelena Mirochnik, Carolyn S. Brecklin, Elaine N. Unemori, Ashok K. Singh, Leonid Slobodskoy, Beverly H. Grove, Jose A.L. Arruda, George Dunea 
Kidney International 
Volume 59, Issue 3, Pages (March 2001)
DOI: /j x
Copyright © 2001 International Society of Nephrology Terms and Conditions

2. Figure 1
Comparison of serum creatinine at five weeks. Bromoethylamine (BEA) + relaxin treatment: BEA one week before, then relaxin treatment for four weeks. *P < 0.05 compared with BEA alone; #P < 0.05 compared with the control.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

3. Figure 2
Comparison of glomerular filtration rate, shown here as creatinine clearance. BEA + relaxin treatment: BEA one week before, then relaxin treatment for four weeks. *P < 0.05 compared with BEA alone; #P < 0.05 compared with the control.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

4. Figure 3
Representative histology of the corticomedullary area at five weeks. (A) BEA alone. (B) BEA + relaxin. Masson's trichrome stain, ×10 at microscope.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

5. Figure 4
Percentage of the corticomedullary area that showed fibrosis. *P < as compared with BEA alone.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

6. Figure 5
Immunohistochemical staining for transforming growth factor-β (TGF-β). (A) BEA alone. There is an increase in the staining intensity in the tubules adjacent to the fibrosis. (B) BEA + Relaxin. There is an apparent decrease in staining intensity in the tubules. Fast red naphthol antibody visualization counterstained with hematoxylin (×10 at microscope).
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

7. Figure 6
Comparison of TGF-β staining intensities. Control 1.56 ± 0.13, BEA 2.77 ± 0.29, BEA + relaxin 1.60 ± BEA + relaxin treatment: BEA one week before, then relaxin treatment for four weeks. *P < 0.05 compared with BEA alone; #P < 0.05 compared with the control.
Kidney International  , DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions