Presentation is loading. Please wait.

Presentation is loading. Please wait.

Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial.

Published byHartono Bambang Sudjarwadi Modified over 5 years ago

Similar presentations

Presentation on theme: "Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial."— Presentation transcript:

1 Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus  Natalia Kozyr, Carly Ziegler, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Taylor Deane, Linda Stempora, Bruce R. Blazar, Leslie S. Kean  Biology of Blood and Marrow Transplantation  Volume 19, Issue 2, Pages S328-S329 (February 2013) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 The Primate GvHD Transcriptome: (A) Principal Component Analysis (PCA) reveals that maximal variation between the arrays was determined by the experimental cohort. (B) Differentially Expressed (DE) Genes Compared to Healthy Controls (HC). Left: Shown Are numbers of Up- (red) and Down- (blue) regulated genes in Auto, Sirolimus, and GvHD cohorts compared to HC. Right: Venn Diagrams showing overlap of DE genes between the three cohorts. (C) Ingenuity Pathway Analysis depicting gene networks differentially regulated during GvHD. Shown are representative networks showing cell cycle (left) and inflammatory response genes (right). Biology of Blood and Marrow Transplantation  , S328-S329DOI: ( /j.bbmt ) Copyright © Terms and Conditions

Download ppt "Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial."

Similar presentations

Identification of CD137+ IFN-g- CD4+ Alloreactive T Cells Post Myeloablative Double Cord Blood Transplant: A Synergistic Role in the Graft Verus Graft.

Identification of CD137+ IFN-g- CD4+ Alloreactive T Cells Post Myeloablative Double Cord Blood Transplant: A Synergistic Role in the Graft Verus Graft.
Exhaustive TCR Deep Sequencing Reveals That CMV Reactivation Fundamentally Resets Immune Reconstitution after Transplant and Results in Significant Deficits.

Exhaustive TCR Deep Sequencing Reveals That CMV Reactivation Fundamentally Resets Immune Reconstitution after Transplant and Results in Significant Deficits.
Trend, Risk Factors and Outcome of Thrombotic Microangiopathy in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Multi-Institutional Review 

Trend, Risk Factors and Outcome of Thrombotic Microangiopathy in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Multi-Institutional Review 
Cédric Carli, Martin Giroux, Jean-Sébastien Delisle 

Cédric Carli, Martin Giroux, Jean-Sébastien Delisle 
National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working.

National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working.
Improvement of Disease Status Determination and Documentation Pre- and Post- Transplant  Michelle Bycko, Crystal Gazaway, Jennifer Holter Chakrabarty,

Improvement of Disease Status Determination and Documentation Pre- and Post- Transplant  Michelle Bycko, Crystal Gazaway, Jennifer Holter Chakrabarty,
How to Treat MDS without Stem Cell Transplantation

How to Treat MDS without Stem Cell Transplantation
Incidence and Causes of Hospital Readmission in Pediatric Patients after Hematopoietic Cell Transplantation  David Stephen Shulman, Wendy B. London, Dongjing.

Incidence and Causes of Hospital Readmission in Pediatric Patients after Hematopoietic Cell Transplantation  David Stephen Shulman, Wendy B. London, Dongjing.
Microsoft Access®: A Viable Blood and Marrow Transplant (BMT) Database Solution  Lindsay Dozeman, Alison Amendola, MHA, Connie Grobe, Lisa Cantwell, MHA,

Microsoft Access®: A Viable Blood and Marrow Transplant (BMT) Database Solution  Lindsay Dozeman, Alison Amendola, MHA, Connie Grobe, Lisa Cantwell, MHA,
High-Content Flow Cytometry and Temporal Data Analysis for Defining a Cellular Signature of Graft-Versus-Host Disease  Ryan Remy Brinkman, Maura Gasparetto,

High-Content Flow Cytometry and Temporal Data Analysis for Defining a Cellular Signature of Graft-Versus-Host Disease  Ryan Remy Brinkman, Maura Gasparetto,
Hematopoietic Cell Transplantation Provides Durable Disease Control in Patients with Double-Hit Lymphoma  Taewoong Choi, Murali K. Kodali, Wen-Kai Weng 

Hematopoietic Cell Transplantation Provides Durable Disease Control in Patients with Double-Hit Lymphoma  Taewoong Choi, Murali K. Kodali, Wen-Kai Weng 
Using A3 Methodology to Identify the Root Cause of a Chemotherapy Error in a Hematopoietic Stem Cell Transplant Patient  Kathlene DeGregory, PharmD, BCOP,

Using A3 Methodology to Identify the Root Cause of a Chemotherapy Error in a Hematopoietic Stem Cell Transplant Patient  Kathlene DeGregory, PharmD, BCOP,
Infusion of Ex Vivo Expanded Cord Blood Progenitor Cells Is Associated with Reduced Hospital Days and Utilization of Opiate Infusion and Total Parenteral.

Infusion of Ex Vivo Expanded Cord Blood Progenitor Cells Is Associated with Reduced Hospital Days and Utilization of Opiate Infusion and Total Parenteral.
IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host.

IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host.
Continuous Intravenous Immunoglobulin and Platelet Infusion in Allogeneic Stem Cell Transplant Patients with Allo-Immune Thrombocytopenia  Katerina Ancevski,

Continuous Intravenous Immunoglobulin and Platelet Infusion in Allogeneic Stem Cell Transplant Patients with Allo-Immune Thrombocytopenia  Katerina Ancevski,
Predictive Value of Pre-Transplant PET/CT Scan before Autologous Stem Cell Transplant in Mantle Cell Lymphoma  Brian Hess, MD, Kathryn Trinkaus, Ph.D.,

Predictive Value of Pre-Transplant PET/CT Scan before Autologous Stem Cell Transplant in Mantle Cell Lymphoma  Brian Hess, MD, Kathryn Trinkaus, Ph.D.,
A First-in-Disease Trial of in Vivo Costimulation Blockade for GVHD Prevention: The Addition of Abatacept to Standard GVHD Prophylaxis Controls Early.

A First-in-Disease Trial of in Vivo Costimulation Blockade for GVHD Prevention: The Addition of Abatacept to Standard GVHD Prophylaxis Controls Early.
Implementation of Post-Transplant Assessment Tools for Improved Accuracy of Graft- Versus-Host Disease Reporting  Madhu Ragupathi, Jaskiran Kaur, Luda.

Implementation of Post-Transplant Assessment Tools for Improved Accuracy of Graft- Versus-Host Disease Reporting  Madhu Ragupathi, Jaskiran Kaur, Luda.
Optimizing Data Collection for Long-Term Follow-Up after Hematopoietic Stem Cell Transplant  Jaskiran Kaur, Madhu Ragupathi, Alysa Pleiner, Luda Kushner,

Optimizing Data Collection for Long-Term Follow-Up after Hematopoietic Stem Cell Transplant  Jaskiran Kaur, Madhu Ragupathi, Alysa Pleiner, Luda Kushner,
Neuroblastoma and Ewing's Sarcoma Associated with ROR1 Expression Can Be Effectively Targeted with NK Cells Modified to Express an Anti ROR1 Chimeric.

Neuroblastoma and Ewing's Sarcoma Associated with ROR1 Expression Can Be Effectively Targeted with NK Cells Modified to Express an Anti ROR1 Chimeric.

Similar presentations

Ads by Google