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Effect of granulocyte-colony stimulating factor on expression of selected proteins involved in regulation of apoptosis in the brain of newborn piglets.

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Presentation on theme: "Effect of granulocyte-colony stimulating factor on expression of selected proteins involved in regulation of apoptosis in the brain of newborn piglets."— Presentation transcript:

1 Effect of granulocyte-colony stimulating factor on expression of selected proteins involved in regulation of apoptosis in the brain of newborn piglets after cardiopulmonary bypass and deep hypothermic circulatory arrest  Peter Pastuszko, MD, Gregory J. Schears, MD, Afsaneh Pirzadeh, MD, Joanna Kubin, MS, William J. Greeley, MD, David F. Wilson, PhD, Anna Pastuszko, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 143, Issue 6, Pages (June 2012) DOI: /j.jtcvs Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Effect of DHCA and G-CSF on Bax, Fas-L, and DR6 immunoreactivities in the frontal cortex of newborn brain. Bars represent the means ± standard error of the mean (SEM) for the density of the bands for 6 independent experiments. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Effect of DHCA and G-CSF on Bcl-2, pAkt, and pJAK2 immunoreactivities in the hippocampus of newborn brain. Bars represent the means ± SEM for the density of the bands for 6 independent experiments. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Effect of DHCA and G-CSF on Bcl-2, pAkt, and pJAK2 immunoreactivities in the striatum of newborn brain. Bars represent the means ± SEM for the density of the bands for 6 independent experiments. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Effect of DHCA and G-CSF on caspase-3, Fas, Fas-L, and DR6 immunoreactivities in striatum of newborn brain. Bars represent the means ± SEM for the density of the bands for 6 independent experiments. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions


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