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Screening for a Diamond in the Rough

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Presentation on theme: "Screening for a Diamond in the Rough"— Presentation transcript:

1 Screening for a Diamond in the Rough
Xiaoqian Wu, Julian G. Hurdle  Chemistry & Biology  Volume 20, Issue 9, Pages (September 2013) DOI: /j.chembiol Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 Screening and Preclinical Path for Hits Dissipating the Membrane’s Electrical Potential—Δψ—or Proton Gradient—ΔpH The inset simplifies the membrane and respiratory chain as drug target sites; compounds are shown as colored triangles; not shown is the peptidoglycan and unknown membrane-embedded proteins that could interact with membrane-active agents. The DiSC3(5) florescence data in the graph was derived from Farha et al. (2013). Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2013 Elsevier Ltd Terms and Conditions


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