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Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy
Zhen Wang, Bryce P. Portier, Bo Hu, Andres Chiesa-Vottero, Jonathan Myles, Gary W. Procop, Raymond R. Tubbs The Journal of Molecular Diagnostics Volume 14, Issue 5, Pages (September 2012) DOI: /j.jmoldx Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions
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Figure 1 Representative photomicrographs of a renal allograft biopsy, showing nuclear inclusions in tubular epithelial cell nuclei consistent with BK virus cytopathic effect; H&E (A) and PAS (B). The Journal of Molecular Diagnostics , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions
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Figure 2 IHC results for SV40 are displayed. Representative image of negative control (A) and representative image of a case positive for BK nephropathy (B). Original magnification: ×20. The Journal of Molecular Diagnostics , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions
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Figure 3 Representative FISH image of a renal allograft biopsy. Individual green signals for chromosome 8 confirm the presence of successful hybridization in both BK positive (red) and BK negative (blue) nuclei. Original magnification, ×60. The Journal of Molecular Diagnostics , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions
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Figure 4 CISH results for BK virus (red) and IHC for CD3 (brown) CISH-PRO images. BK virus and CD3 detection via CISH-PRO in the absence (A) and in the presence (B) of significant interstitial or intratubular inflammation. The Journal of Molecular Diagnostics , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions
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