Presentation is loading. Please wait.

Presentation is loading. Please wait.

Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy

Similar presentations


Presentation on theme: "Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy"— Presentation transcript:

1 Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy
Zhen Wang, Bryce P. Portier, Bo Hu, Andres Chiesa-Vottero, Jonathan Myles, Gary W. Procop, Raymond R. Tubbs  The Journal of Molecular Diagnostics  Volume 14, Issue 5, Pages (September 2012) DOI: /j.jmoldx Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 Representative photomicrographs of a renal allograft biopsy, showing nuclear inclusions in tubular epithelial cell nuclei consistent with BK virus cytopathic effect; H&E (A) and PAS (B). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 IHC results for SV40 are displayed. Representative image of negative control (A) and representative image of a case positive for BK nephropathy (B). Original magnification: ×20. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

4 Figure 3 Representative FISH image of a renal allograft biopsy. Individual green signals for chromosome 8 confirm the presence of successful hybridization in both BK positive (red) and BK negative (blue) nuclei. Original magnification, ×60. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

5 Figure 4 CISH results for BK virus (red) and IHC for CD3 (brown) CISH-PRO images. BK virus and CD3 detection via CISH-PRO in the absence (A) and in the presence (B) of significant interstitial or intratubular inflammation. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions


Download ppt "Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy"

Similar presentations


Ads by Google