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A Novel Fusion of TPR and ALK in Lung Adenocarcinoma

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1 A Novel Fusion of TPR and ALK in Lung Adenocarcinoma
Yoon-La Choi, MD, PhD, Maruja E. Lira, BS, Mineui Hong, MD, Ryong Nam Kim, PhD, So-Jung Choi, PhD, Ji-Young Song, MS, Kinnari Pandy, MS, Derrick L. Mann, PhD, Joshua A. Stahl, PhD, Heather E. Peckham, PhD, Zongli Zheng, MD, PhD, Joungho Han, PhD, Mao Mao, MD, PhD, Jhingook Kim, MD, PhD  Journal of Thoracic Oncology  Volume 9, Issue 4, Pages (April 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 A, Chest computed tomography with a 51-mm irregular mass in the right upper lobe (arrow). B, Cut surface of the lobectomy specimen showing a lobulating grayish and yellow-tan solid mass. C, Hematoxylin and eosin staining shows adenocarcinoma with a solid pattern (×200). D, ALK immunohistochemical staining shows diffuse cytoplasmic pattern (×200). E and F, FISH assay of the ALK genomic rearrangement with split 5’- and 3’-probe signals (red and green arrows) with occasionally increased ALK copy number. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 A, Schematic structure of the genomic DNA sequence (upper) and DNA sequence chromatograms (lower) showing fusion points for genomic rearrangement and TPR-ALK fusion transcript cDNA. B, Functional domain structures of TPR, ALK, and TPR-ALK proteins. TPR, translocated promoter region; ALK, anaplastic lymphoma kinase; JM, juxtamembrane. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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