Download presentation
Presentation is loading. Please wait.
1
Volume 73, Pages S34-S41 (April 2008)
Clinical outcomes and peritoneal histology in patients starting peritoneal dialysis are related to diabetic status and serum albumin levels J.-C. Contreras-Velázquez, V. Soto, Y. Jaramillo-Rodríguez, L.-I. Samaniego-Ríos, V. Quiñones-Pérez, M. Ávila, D. Amato, R. Paniagua Kidney International Volume 73, Pages S34-S41 (April 2008) DOI: /sj.ki Copyright © 2008 International Society of Nephrology Terms and Conditions
2
Figure 1 Parietal peritoneal biopsies (original magnification × 200) stained with (a–c) hematoxylin and eosin (H&E) and (d–f) Masson's trichrome. Peritoneum from an NU-ND patient (control group) appears without histological alterations. (a, d) Mesothelial cells appear as monolayer and no stroma alterations. Peritoneum from a U-ND patient. Mesothelium is preserved but hyperplasic and reactive. (b, e) Blood vessels are increased in number. (c, f) Peritoneum from a U-D patient where intermittent mesothelium, vascular sclerosis, and perivascular inflammatory cells are observed. The last images (original magnification × 400) in (g–i), stained with H&E, are from U-D patients in which perivascular inflammatory cells are observed. Kidney International , S34-S41DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions
3
Figure 2 Immunostaining HBME-1 (mesothelium antibody) of mesothelial surface layer of the parietal peritoneum (original magnification × 1000). (a, b) Cells from mesothelium of control group are organized in a continuous row without any alterations. Mesothelium from the U-ND group has reactive changes and the nuclei are irregular. (c, d) Microvilli are preserved although there is shortening. Mesothelium from the U-D group display discohesive cellular surface and massive infiltration of granulocytes and macrophages. (e, f) Positive immunostained cells have reactive changes with vacuolization of cytoplasm. Kidney International , S34-S41DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions
4
Figure 3 Parietal peritoneal biopsies immunostained with CD45 (common leukocytary antigen) (original magnification × 200). Peritoneum from a control patient (a) without inflammatory infiltration and peritoneum from a U-ND patient (b) with a few inflammatory cells in a field. (c) In the U-D patients, many perivascular inflammatory cells are observed. Kidney International , S34-S41DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions
5
Figure 4 Graph shows the role of inflammatory infiltration on patient survival. Chronic inflammatory infiltration or the combination of chronic and acute inflammatory infiltration exerts adverse outcomes in patients starting in a PD program. The graph represents the model 1 in Table 5. Kidney International , S34-S41DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.