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The Effect of Granulocyte Colony–Stimulating Factor on Immune-Modulatory Cytokines in the Bone Marrow Microenvironment and Mesenchymal Stem Cells of Healthy.

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Presentation on theme: "The Effect of Granulocyte Colony–Stimulating Factor on Immune-Modulatory Cytokines in the Bone Marrow Microenvironment and Mesenchymal Stem Cells of Healthy."— Presentation transcript:

1 The Effect of Granulocyte Colony–Stimulating Factor on Immune-Modulatory Cytokines in the Bone Marrow Microenvironment and Mesenchymal Stem Cells of Healthy Donors  Ikbal Ok Bozkaya, Fatih Azik, Betul Tavil, Yasin Koksal, Meltem Ozguner, Bahattin Tunc, Duygu Uckan Cetinkaya  Biology of Blood and Marrow Transplantation  Volume 21, Issue 11, Pages (November 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 In vitro differentiation of G-BM–derived MSCs into adipocytes (×4 magnification). (A) Unstained, (B) oil o red staining, (C) unstained, (D) oil o red staining. (This figure is available in color online at Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 In vitro differentiation of G-BM–derived MSCs into osteocytes (×4 magnification). (A) Unstained, (B) alizarin red staining, (C) unstained, (D) alizarin red staining. (This figure is available in color online at Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Concentration of HGF, TGFβ1, and PGE2 in MSCs supernatants and BM plasma. *In the BM plasmas, HGF with G-CSF increase. **In the MSCs supernatants, PGE2 with G-CSF decrease. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions


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