1. MexT-associated downregulation of oprD expression.
MexT-associated downregulation of oprD expression. Transcription of oprD in wild-type P. aeruginosa PAO1 initiates from two start sites, SS1 and SS2. MexT-associated downregulation of oprD expression is associated with a selective inhibition of transcription from SS1 (278). The model proposed in this figure involves the binding of a regulatory protein, potentially MexT, with or without cofactors, within the promoter region between SS1 and SS2, blocking efficient initiation of transcription from SS1.
Philip D. Lister et al. Clin. Microbiol. Rev. 2009; doi: /CMR