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Comparison of Frequency and Sensitivity of BCR-ABL1 Kinase Domain Mutations in Asian and White Patients With Imatinib-resistant Chronic–Phase Chronic.

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Presentation on theme: "Comparison of Frequency and Sensitivity of BCR-ABL1 Kinase Domain Mutations in Asian and White Patients With Imatinib-resistant Chronic–Phase Chronic."— Presentation transcript:

1 Comparison of Frequency and Sensitivity of BCR-ABL1 Kinase Domain Mutations in Asian and White Patients With Imatinib-resistant Chronic–Phase Chronic Myeloid Leukemia  Hawk Kim, SooHyun Kim, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Jae-Yong Kwak, Ho-Young Yhim, Sung-Hyun Kim, Young Rok Do, Sukjoong Oh, Sung-Eun Lee, Saengsuree Jootar, Jiu Wei Cui, Dong-Wook Kim  Clinical Lymphoma, Myeloma and Leukemia  Volume 18, Issue 10, Pages e391-e399 (October 2018) DOI: /j.clml Copyright © 2018 The Authors Terms and Conditions

2 Figure 1 Frequency of Patients With Single and Multiple BCR-ABL1 Mutations. The Frequencies of Mutations and Proportions of Single or Multiple Mutations Were Assessed by Race. Blue, Single Mutations; Red, Multiple Mutations Clinical Lymphoma, Myeloma and Leukemia  , e391-e399DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

3 Figure 2 Frequency of BCR-ABL1 Mutations by In Vitro Sensitivity. (A) Mutations Occurring in the Study Populations Were Analyzed by the Degree to Which They Contributed to Resistance To (1) Bosutinib, (2) Dasatinib, and (3) Nilotinib in Each Cohort. (B) Comparison of Mutations by In Vitro Sensitivity and Race. Only Patients With a Single Mutation Were Included. Green, Sensitive (50% Inhibitory Concentration [IC50]-Fold Increase ≤ 2); Yellow, Moderately Resistant (IC50-Fold Increase > 2-4); Orange, Resistant (IC50-Fold Increase > 4-10); Red, Highly Resistant (IC50-Fold Increase > 10); Gray, Unknown Clinical Lymphoma, Myeloma and Leukemia  , e391-e399DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions


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