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Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule.

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Presentation on theme: "Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule."— Presentation transcript:

1 Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule expression  Tomoaki Kusume, M.D., Nagamasa Maeda, M.D., Ph.D., Chiaki Izumiya, M.D., Ph.D., Yorito Yamamoto, M.D., Kazutoshi Hayashi, M.D., Ph.D., Hiroyoshi Oguri, M.D., Ph.D., Yoshiko Nishimori, B.Sc., Takao Fukaya, M.D., Ph.D.  Fertility and Sterility  Volume 83, Issue 4, Pages (April 2005) DOI: /j.fertnstert Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Determination of fluorescence intensities and activation ratios for human leukocyte antigen HLA-DR and CD14 by flow cytometry in women with endometriosis. (A) Peripheral blood (PB) monocytes. (B) Peritoneal fluid (PF) macrophages. Control subjects are shown on the left within each panel. Mean HLA-DR fluorescence intensity among CD14+ HLA-DR+ cells in PF macrophages (b-cont.2) was divided by that in PB monocytes (a-cont.1) as an index of macrophage activation potential (macrophage activation ratio) [(b-cont.2)/(a-cont.1)], as also was done for HLA-ABC and costimulatory molecules. Cont, control. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Correlation between fluorescence intensities of human leukocyte antigen (HLA) and costimulatory molecules on peritoneal macrophages in women with endometriosis. (A) Correlation between HLA-ABC and costimulatory molecules. (B) Correlation between HLA-DR and costimulatory molecules. Correlation was assessed by linear regression analysis. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 Correlation between fluorescence intensities of human leukocyte antigen (HLA) and costimulatory molecules on peritoneal macrophages in women without endometriosis. (A) The correlation between HLA-ABC and costimulatory molecules. (B) The correlation between HLA-DR and costimulatory molecules. Correlation was assessed by linear regression analysis. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions


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