Presentation is loading. Please wait.

Presentation is loading. Please wait.

Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte.

Similar presentations


Presentation on theme: "Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte."— Presentation transcript:

1 Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group  Thomas Schroeder, Elena Rachlis, Gesine Bug, Matthias Stelljes, Stefan Klein, Nina Kristin Steckel, Dominik Wolf, Mark Ringhoffer, Akos Czibere, Kathrin Nachtkamp, Ariane Dienst, Mustafa Kondakci, Michael Stadler, Uwe Platzbecker, Lutz Uharek, Thomas Luft, Roland Fenk, Ulrich Germing, Martin Bornhäuser, Nicolaus Kröger, Dietrich W. Beelen, Rainer Haas, Guido Kobbe  Biology of Blood and Marrow Transplantation  Volume 21, Issue 4, Pages (April 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Overall survival (OS) after treatment with Aza and DLI in 154 patients. OS was 29% (±4%) at 2 years. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Overall survival (OS) after treatment with Aza and DLI according to diagnosis and disease burden. Type of relapse (eg, molecular instead of hematological relapse), primary diagnosis of MDS, and a lower leukemic burden in BM at relapse were associated with a longer OS in multivariate analysis. (A) Patients with MDS (blue curve) and AML (green curve), log-rank: P = (B) AML patients according to type of relapse and BM blast count: molecular relapse (blue curve, log-rank: P < .001), hematological relapse <13% blasts (green curve, log-rank: P = .0602), and hematological relapse >13% blasts (grey curve). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions


Download ppt "Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte."

Similar presentations


Ads by Google