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Polycomb Repression under the Skin

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Presentation on theme: "Polycomb Repression under the Skin"— Presentation transcript:

1 Polycomb Repression under the Skin
Vincenzo Pirrotta  Cell  Volume 136, Issue 6, Pages (March 2009) DOI: /j.cell Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Polycomb Proteins Regulate a Gene Hierarchy in Differentiation (A) In embryonic stem (ES) cells, mechanisms mediated by Polycomb group (PcG) proteins contribute to the stability of the pluripotent state at multiple levels in the gene hierarchy. (B) Once cells enter the epidermal pathway, the upper levels of the hierarchy, as well as alternative differentiation pathways, are permanently shut off by PcG-independent mechanisms. PcG regulation now moves down the gene hierarchy to control the proper deployment of epidermal differentiation genes. Cell  , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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