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Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia  Steven.

Published byÊÊΔιομήδης Κουρμούλης Modified over 5 years ago

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Presentation on theme: "Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia  Steven."— Presentation transcript:

1 Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia  Steven P. Hopkins, MD, Jeffrey P. Bulgrin, BS, Rick L. Sims, BS, Brad Bowman, BS, Duane L. Donovan, MD, Steven P. Schmidt, PhD  Journal of Vascular Surgery  Volume 27, Issue 5, Pages (May 1998) DOI: /S (98) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Diagram of partial ischemia and VEGF delivery produced in left hind limb of each rabbit. Right hind limb served as a nonischemic control. Ligated vessels are indicated. Left internal iliac artery served as a nutrient vessel for VEGF delivery to adjacent ischemic tissue. Journal of Vascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 A, Representative angiogram of VEGF-treated ischemic (left) rabbit hind limb at postoperation day 40. B, Representative angiogram of saline-treated ischemic (left) rabbit hind limb at postoperation day 40. All angiograms were digitized and evaluated with fractal analysis software program to quantify complexity of vascular branching and overall vascular density. Journal of Vascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 A, Representative transverse section of VEGF-treated ischemic (left) rabbit gastrocnemius muscle at postoperation day 40 (hematoxylin-eosin staining, original magnification ×400). Note uniform muscle fascicle size and shape, with numerous capillary nuclei. B, Transverse section of saline-treated ischemic (left) rabbit gastrocnemius muscle at postoperation day 40 (hematoxylin-eosin staining, original magnification ×400). Saline-treated tissue had irregular, nonuniform fascicles, with fewer capillary nuclei. Journal of Vascular Surgery  , DOI: ( /S (98) ) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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