1. Contemporary Clinical Opioid Use: Opportunities and Challenges
William L. Lanier, MD, Evan D. Kharasch, MD, PhD 
Mayo Clinic Proceedings 
Volume 84, Issue 7, Pages (July 2009)
DOI: /
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2. FIGURE 1
Total US prescriptions dispensed annually for all opioid analgesics from Adapted from the IMS Health, National Prescription Audit Plus.17
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

3. FIGURE 2
Annual numbers (in millions) of new nonmedical users of pain relievers who are 12 years or older, from From the National Survey on Drug Use and Health,
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

4. FIGURE 3
Prescription opioid analgesic deaths nationwide, from Adapted from the National Drug Intelligence Center: National Prescription Drug Threat Assessment
Mayo Clinic Proceedings  , DOI: ( / )
Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions