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Volume 4, Issue 1, Pages (July 2001)

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Presentation on theme: "Volume 4, Issue 1, Pages (July 2001)"— Presentation transcript:

1 Volume 4, Issue 1, Pages 52-57 (July 2001)
Effects of Linear Polyethylenimine and Polyethylenimine/DNA on Lung Function after Airway Instillation to Rat Lungs  Aima N. Uduehi, Uz Stammberger, Bartosz Kubisa, Matthias Gugger, Thomas A. Buehler, Ralph A. Schmid  Molecular Therapy  Volume 4, Issue 1, Pages (July 2001) DOI: /mthe Copyright © 2001 American Society for Gene Therapy Terms and Conditions

2 Fig. 1 Luciferase expression in rat lungs 24 h and 72 h after instillation of naked DNA or DNA/PEI. Data represent the mean ± SEM. *P < compared with DNA/PEI 24 h. Molecular Therapy 2001 4, 52-57DOI: ( /mthe ) Copyright © 2001 American Society for Gene Therapy Terms and Conditions

3 Fig. 2 Gas exchange of the transfected left lung after exclusion of the right lung 24 h (A) or 72 h (B) after instillation of glucose, naked DNA, DNA/PEI, or PEI. Data represent the mean ± SEM. *P < compared with rats treated with naked DNA. Molecular Therapy 2001 4, 52-57DOI: ( /mthe ) Copyright © 2001 American Society for Gene Therapy Terms and Conditions

4 Fig. 3 Histological findings in rat lungs 24 h (A–F) or 72 h (G–N) after instillation of glucose (A, B, G, H), naked DNA (C, D, I, J), DNA/PEI (E, F, K, L), or PEI (M, N). Sections were cut to 3 thick and stained with hematoxylin and eosin. Magnification, x100. Molecular Therapy 2001 4, 52-57DOI: ( /mthe ) Copyright © 2001 American Society for Gene Therapy Terms and Conditions


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