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Golgi Feels DNA’s Pain Cell

Published byMagdalene Harris Modified over 5 years ago

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Presentation on theme: "Golgi Feels DNA’s Pain Cell"— Presentation transcript:

1 Golgi Feels DNA’s Pain Cell
Marco Foiani, Jiri Bartek  Cell  Volume 156, Issue 3, Pages (January 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 DNA-PK-Mediated Golgi Regulation in Response to DNA Damage
Chromatin is physically connected to the nuclear envelope, which is continuous with the endoplasmic reticulum (ER). Membrane contact sites connect the ER with the Golgi apparatus and with the plasma membrane. GOLPH3 (dark blue shape) is attached to actin (black lines). DNA double-strand breaks generate a signal (red dot) leading to GOLPH3 phosphorylation through a process (arrow) mediated by DNA-PK, inducing Golgi dispersal, impaired intracellular trafficking, and enhanced cell survival. The zoomed-in area depicts DNA-PK-mediated phosphorylation of the critical T143/T148 residues of GOLPH3. Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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