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Volume 130, Issue 6, Pages 1679-1687 (May 2006)
Identification of Two Gene Variants Associated With Risk of Advanced Fibrosis in Patients With Chronic Hepatitis C Hongjin Huang, Mitchell L. Shiffman, Ramsey C. Cheung, Thomas J. Layden, Scott Friedman, Olivia T. Abar, Linda Yee, Anand P. Chokkalingam, Steven J. Schrodi, Jason Chan, Joseph J. Catanese, Diane U. Leong, David Ross, Xiaolan Hu, Alexander Monto, Linda B. McAllister, Samuel Broder, Thomas White, John J. Sninsky, Teresa L. Wright Gastroenterology Volume 130, Issue 6, Pages (May 2006) DOI: /j.gastro Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions
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Figure 1 Strategy and work flow of association study.
Gastroenterology , DOI: ( /j.gastro ) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions
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Figure 2 Additional SNPs in DDX5 region and risk of advanced fibrosis. *SNP7 is the original DDX5 SNP. aAdjusted for sex, alcohol, and ethnicity. bHap window indicates the 3 SNPs included for each window (Figure 3A). cSNPs in bold are the ones in Hap windows 4 and 5 and candidates for diplotype analysis. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions
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Figure 3 (A) Haplotype window in DDX5 region and risk of advanced firbosis. (B) DDX5-POLG2 diplotypes and risk of advanced fibrosis. aAll analyses were adjusted for sex, alcohol, and ethnicity. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions
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Figure 4 Clinical and genetic factors: risk of advanced fibrosis. Odds ratios. To make the results comparable, all clinical and genetic risk factors were adjusted for sex, alcohol, and ethnicity Lines indicate 95% confidence intervals of odds ratios; numbers next to each line are P values. Dotted line indicates an odds ratio equals to 1. aPopulation at risk indicates the percentage of subjects carrying the risk factors. bThe odds ratio of CPT1A SNP was reversed to be consistent with other factors; therefore, the odds ratio for this SNP should be explained as protective effect. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions
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