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The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994–2010)  Sandra E.

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Presentation on theme: "The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994–2010)  Sandra E."— Presentation transcript:

1 The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994–2010)  Sandra E. Kleiman, Ph.D., Leah Yogev, Ph.D., Ofer Lehavi, M.D., Ron Hauser, M.D., Amnon Botchan, M.D., Gedalia Paz, Ph.D., Haim Yavetz, M.D., Ronni Gamzu, M.D., Ph.D.  Fertility and Sterility  Volume 95, Issue 6, Pages e4 (May 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

2 Study selection chart. Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

3 Six newly reported men evaluated in our institution with deletions in relation to the sequence of the Y-chromosome. (A) The palindromic structure encompassing the AZFb-c region. (B) The STSs used in the study: the tick marks show STS positions, ticks on the horizontal line denote single-copy STSs, and ticks down the horizontal line denote multicopy STSs. (C) Plus/minus STS results for the six infertile men with AZFb-c or AZFb deletions. Horizontal black bars indicate confirmed presence of the DNA, and minus signs indicate confirmed absence of the DNA region. Horizontal gray bars indicate multicopy STS positives that were disregarded because of cross-amplifying loci and negative results for flanking STSs. (D) Predicted and confirmed genes. (E) Apparently noncoding transcripts. Panels (A), (D), and (E) were according to Repping et al (6). Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions


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