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Peritoneal Free Autologous Fat Graft for the Control of Pulmonary Air Leaks in Emphysematous Rat Lungs  Cristiano F. Andrade, MD, PhD, Eduardo Fontena,

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Presentation on theme: "Peritoneal Free Autologous Fat Graft for the Control of Pulmonary Air Leaks in Emphysematous Rat Lungs  Cristiano F. Andrade, MD, PhD, Eduardo Fontena,"— Presentation transcript:

1 Peritoneal Free Autologous Fat Graft for the Control of Pulmonary Air Leaks in Emphysematous Rat Lungs  Cristiano F. Andrade, MD, PhD, Eduardo Fontena, MD, Paulo F.G. Cardoso, MD, PhD, Raôni B. Pereira, MD, Gustavo Grun, MD, Luiz F. Forgiarini, BS, José S. Moreira, MD, PhD, José C. Felicetti, MD, PhD  The Annals of Thoracic Surgery  Volume 98, Issue 1, Pages (July 2014) DOI: /j.athoracsur Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Diaphragmatic aspect of the emphysematous right lower lobe inflated (positive end-expiratory pressure [PEEP] 5 cmH2O): (A) penetrating lung injury shows the air leak (arrow); (B) the same lobe with the fat graft inserted into the lung parenchyma, showing no air leak (arrow). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Emphysematous rat lungs showing the fat graft vessels stained with India ink (arrows) at (A) 7 days and at (B) 60 days. (Hematoxylin and eosin: ×100 high-power field.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 (A) A positive correlation is shown between the increase in caspase 3 and factor VIII in the emphysema lungs. A negative correlation is shown between the decrease in vascular endothelial growth factor (VEGF) expression with the rise in both (B) caspase 3 and (C) factor VIII. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 A 61-year-old man with emphysema underwent left basilar segmentectomy for metastatic colon cancer. (A) Pericardial fat (arrow) is isolated. (B) Free pericardial fat is sutured on the lung surface (arrow). Chest computed tomography scans show the free pericardial fat graft within the lung parenchyma (arrows) at (C) 36 hours and (D) 8 months after surgery. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

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