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Atypical Primary Epithelioid Hemangioendothelioma of the Heart

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1 Atypical Primary Epithelioid Hemangioendothelioma of the Heart
N Moulai, MD, O Chavanon, MD, PhD, L Guillou, MD, PhD, M Noirclerc, MD, D Blin, MD, E Brambilla, MD, S Lantuejoul, MD, PhD  Journal of Thoracic Oncology  Volume 1, Issue 2, Pages (February 2006) DOI: /S (15) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1. Histological examination of the primary cardiac tumor revealed a proliferation of large epithelioid tumor cells presenting atypical features (arrow). Hematoxylin-eosin-saffron staining; original magnification ×400. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2. Pulmonary metastasis corresponding to a classical nodular lesion, with a hypocellular fibrotic center and a more cellular periphery, composed of tumor cells that typically spread into the bronchioloalveolar lumen in a polypoid fashion. Hematoxylin-eosin-saffron staining; original magnification ×200. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3. A, At higher magnification, epithelioid tumor cells harbor regular nuclei and large vacuolated cytoplasms containing rare red blood cells (arrow). Hematoxylin-eosin-saffron staining; original magnification ×400. B, CD 34 immunostaining enlightening primitive intracellular vascular channels (arrow). Immunoperoxidase staining; original magnification ×400. Journal of Thoracic Oncology 2006 1, DOI: ( /S (15) ) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

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