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Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

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Presentation on theme: "Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines"— Presentation transcript:

1 Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines
Chakkumkal Anish, Benjamin Schumann, Claney Lebev Pereira, Peter H. Seeberger  Chemistry & Biology  Volume 21, Issue 1, Pages (January 2014) DOI: /j.chembiol Copyright © 2014 Elsevier Ltd Terms and Conditions

2 Figure 1 The Immunogenic Determinants of a Synthetic Carbohydrate Antigen Size/span of the epitope (1), terminal glycan residues (2), presence of branching points (3), side chain functional groups (4), and number of repeating units (5). L, preinstalled linker for conjugation. Chemistry & Biology  , 38-50DOI: ( /j.chembiol ) Copyright © 2014 Elsevier Ltd Terms and Conditions

3 Figure 2 Major Steps Involved in Rational Design of Synthetic Carbohydrate Vaccines ∗Reprinted with permission from Oberli et al. (2010). Copyright (2010) American Chemical Society. Chemistry & Biology  , 38-50DOI: ( /j.chembiol ) Copyright © 2014 Elsevier Ltd Terms and Conditions

4 Figure 3 The Structure of Man9GlcNAc2 on HIV Protein gp120 Interacting with the Broadly Neutralizing mAb 2G12 Adapted from Lee et al. (2004). Chemistry & Biology  , 38-50DOI: ( /j.chembiol ) Copyright © 2014 Elsevier Ltd Terms and Conditions


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