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SOX9 transcriptional activity is dependent on the chondrocyte health state and is directly regulated by WNT3A, IL1β and BMP7  K. Govindaraj, M. Karperien,

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Presentation on theme: "SOX9 transcriptional activity is dependent on the chondrocyte health state and is directly regulated by WNT3A, IL1β and BMP7  K. Govindaraj, M. Karperien,"— Presentation transcript:

1 SOX9 transcriptional activity is dependent on the chondrocyte health state and is directly regulated by WNT3A, IL1β and BMP7  K. Govindaraj, M. Karperien, J.N. Post  Osteoarthritis and Cartilage  Volume 25, (April 2017) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1 FRAP time lapse images showing SOX9-mGFP recovery after photobleaching. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2A FRAP curve showing change of SOX9-mGFP mobility in response to WNT3A. WNT antagonists DKK1 and FRZB restore SOX9-mGFP mobility in preserved chondrocytes. *p<0.05, **p<0.01 Mann-Whitney U test. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions


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