1. acquired immunity humoral response antibodies (tag invaders)
diversity (CDR)
five major types…
secreted, circulating, tissue (IgA…)
produced by B cells (clones)
cell mediated response
B cells (plasma, memory)
TH cells
TC cells (cytotoxic)
macrophages, PMNLs
communication via cytokines

2. Fab VH VL
CH3 CL
CH2
CH1 Fc

3. “framework”

4. CDR

5. Fab VH VL
CH3 CL
CH2
CH1 Fc

7. acquired immunity humoral response antibodies (tag invaders)
diversity (CDR)
five major types…
secreted, circulating, tissue
produced by B cells
cell mediated response
B cells (plasma, memory)
TH cells
TC cells
macrophages
communication via cytokines

8. acquired immunity invader… antigen (epitope, determinant)
five main kinds: viruses, bacteria, fungi, “protozoa”, metazoan parasites
antigen (epitope, determinant)

9. acquired immunity antibody diversity antigen independent proliferation
B cell
B cell
antibody diversity
antigen independent proliferation
B cell

10. acquired immunity
B cell

11. acquired immunity
B cell
MAC

12. acquired immunity
B cell
MAC

13. acquired immunity
B cell
MAC

14. acquired immunity
B cell
MAC
MHC
APC

15. acquired immunity
B cell
MAC TH

16. acquired immunity
B cell
MAC TH

17. TH
acquired immunity
B cell TH
MAC TH TH TH

18. acquired immunity
B cell
MAC TH

19. acquired immunity plasma B cells anitgen dependent proliferation
memory B cell

20. acquired immunity plasma B cells memory B cell B cell B cell B cell

21. acquired immunity plasma B cells ?? memory B cell B cell B cell B cell

22. acquired immunity
MAC
MAC
MAC
MAC

23. acquired immunity
MAC
MAC
MAC
MAC

24. acquired immunity
B cell
memory B cell

25. acquired immunity plasma B cells memory B cell B cell B cell B cell

26. acquired immunity plasma B cells memory B cell B cell B cell B cell

27. acquired immunity
MAC
MAC
MAC
B cell
memory B cell
MAC

28. acquired immunity
PMNLs

29. acquired immunity
PMNLs
ADCC…
ROSs
RNSs
Perforins

30. acquired immunity
PMNLs
ADCC…
ROSs
RNSs
Perforins

31. acquired immunity
MAC

32. acquired immunity

33. acquired immunity

34. acquired immunity
APC

35. acquired immunity TH

36. acquired immunity TC TH

37. acquired immunity TC
perforins…
apoptosis

38. acquired immunity TC

39. basics of epidemiology
the study of diseases in populations
endemic disease…
epidemic disease…
pandemic disease…

40. basics of epidemiology

41. basics of epidemiology
the chain of infection…

42. basics of epidemiology
The pathogen
isolate
identify
associate
introduce
the chain of infection…

43. basics of epidemiology
The source
humans
animals
the chain of infection…

44. basics of epidemiology
Transmission
contact
airborne
the environment
vectors
the chain of infection…

45. basics of epidemiology
Susceptibility
virulence
immunity
the chain of infection…

46. basics of epidemiology
Exit from host
sanitation
hygiene
exposure to vector
the chain of infection…