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Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma  Sheena D. Brown, PhD, Lou Ann Brown, PhD, Susan Stephenson, PhD,

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Presentation on theme: "Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma  Sheena D. Brown, PhD, Lou Ann Brown, PhD, Susan Stephenson, PhD,"— Presentation transcript:

1 Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma 
Sheena D. Brown, PhD, Lou Ann Brown, PhD, Susan Stephenson, PhD, Jennifer C. Dodds, PhD, Shaneka L. Douglas, BS, Hongyan Qu, MS, Anne M. Fitzpatrick, PhD  Journal of Allergy and Clinical Immunology  Volume 135, Issue 6, Pages (June 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Plasma concentrations of TNF-α (A) and mRNA gene expression of TNF (B), CHUK (C), IKBKB (D), NFKBIA (E), and NFKB1 (F) in healthy control subjects (C), children with mild asthma (MA), and children with moderate-to-severe asthma (MSA). Horizontal lines represent the median. *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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