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Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep  M. Ratajczak-Enselme, J.-P. Estebe,

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Presentation on theme: "Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep  M. Ratajczak-Enselme, J.-P. Estebe,"— Presentation transcript:

1 Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep  M. Ratajczak-Enselme, J.-P. Estebe, F.-X. Rose, E. Wodey, J.-M. Malinovsky, F. Chevanne, G. Dollo, C. Ecoffey, P. Le Corre  British Journal of Anaesthesia  Volume 99, Issue 6, Pages (December 2007) DOI: /bja/aem291 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Experimental protocol for the study.
British Journal of Anaesthesia  , DOI: ( /bja/aem291) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Mean (bold) and individual concentration–time profiles in epidural space after epidural administration of ropivacaine (50 mg) and bupivacaine (30 mg) with and without epinephrine. British Journal of Anaesthesia  , DOI: ( /bja/aem291) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Mean (bold) and individual concentration–time profiles in intrathecal space after epidural administration of ropivacaine (50 mg) and bupivacaine (30 mg) with and without epinephrine. British Journal of Anaesthesia  , DOI: ( /bja/aem291) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Mean (bold) and individual concentration–time profiles in plasma after epidural administration of ropivacaine (50 mg) and bupivacaine (30 mg) with and without epinephrine. British Journal of Anaesthesia  , DOI: ( /bja/aem291) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

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