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Resistance integrons and super-integrons

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1 Resistance integrons and super-integrons
A.C. Fluit, F.-J. Schmitz  Clinical Microbiology and Infection  Volume 10, Issue 4, Pages (April 2004) DOI: /j X x Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

2 Fig. 1 Schematic representation of a class 1 integron. P1, promoter for trancription of gene cassettes; P2, second promoter that is usually inactive; int, integrase gene; attI1, integration site; qacE, partially deleted gene that encodes quaternary ammonium compound resistance; sulI, sulphonamide resistance; orf5, unknown function; P, promoters of the qacEΔ and sulI genes; attC, sequence on the gene cassette recognised by the integrase. Clinical Microbiology and Infection  , DOI: ( /j X x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

3 Fig. 2 Schematic presentation of In6-like class 1 integrons, their gene cassettes and additional genes. The direction of transcription for orf1005, ampC, yqgF, and yqgE is opposite to those for the gene cassettes, as indicated by the arrow. In pSAL-1, orf341 is present instead of the closely related orf513. These genes differ only by the insertion of a G at position 960 of orf341 to yield orf513 [94–96,104,140]. Clinical Microbiology and Infection  , DOI: ( /j X x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

4 Fig. 3 Schematic presentation of the attI1 site. The essential part of the attI1 site is formed by the simple site, the strong binding site and the intervening sequence. For details see Hall et al. [123]. Clinical Microbiology and Infection  , DOI: ( /j X x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

5 Fig. 4 Schematic presentation of an attC site. The vertical arrow indicates the recombination point. The core site sequences of the simple sites are boxed. For details see text and Hall et al. [123]. Clinical Microbiology and Infection  , DOI: ( /j X x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions


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