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Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats  J. Hudson, M. West, Y. Fu, T. Griffin  Osteoarthritis.

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Presentation on theme: "Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats  J. Hudson, M. West, Y. Fu, T. Griffin  Osteoarthritis."— Presentation transcript:

1 Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats  J. Hudson, M. West, Y. Fu, T. Griffin  Osteoarthritis and Cartilage  Volume 21, Pages S53-S54 (April 2013) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1 Knee OA scores in leptin receptor mutant Zucker fatty rats (A) and F344BN rats undergoing chronic systemic leptin treatment (B). Obesity in the absence of leptin signaling and increased systemic leptin in the absence of obesity were both sufficient to induce site-specific increases in spontaneous knee OA (∗p<0.05). Osteoarthritis and Cartilage  , S53-S54DOI: ( /j.joca ) Copyright © Terms and Conditions


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