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Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy  Peer Arts, BSc, Frank L. van de Veerdonk, MD, PhD, Robin van.

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Presentation on theme: "Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy  Peer Arts, BSc, Frank L. van de Veerdonk, MD, PhD, Robin van."— Presentation transcript:

1 Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy 
Peer Arts, BSc, Frank L. van de Veerdonk, MD, PhD, Robin van der Lee, MSc, Martijn A. Langereis, PhD, Christian Gilissen, PhD, Wendy A.G. van Zelst-Stams, MD, PhD, Martijn A. Huynen, PhD, Jos W.M. van der Meer, MD, PhD, Frank J. van Kuppeveld, PhD, Joris A. Veltman, PhD, Bart Jan Kullberg, MD, PhD, Alexander Hoischen, PhD, Mihai G. Netea, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 3, Pages (September 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Immunological defect in patients with HSV compared with controls. IFN-γ levels (y-axis) were measured after in vitro stimulations with polyI:C(A) (A), Staphylococcus aureus (B), or Candida albicans (C). In vitro stimulations were performed of PBMCs from patients and compared with 12 controls (x-axis). After 48 hours of stimulation, IFN-γ production was measured by an ELISA. The normal C albicans–induced IFN-γ response in patients 1 and 2 implicates the specific polyI:C and S aureus defect in our patients. HK, Heat killed. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Treatment overview for IFN-γ in our patients shows the recurrent HSV infections over time (t). Severe HSV infections are significantly reduced during the periods with IFN-γ therapy, and relapsed during the periods when treatment was stopped. Mild HSV infections were sporadically observed during periods of rIFN-γ treatment. Patient 3 shows the different infections over time (t). HSV infections similar to Steven-Johnson syndrome starting at age 16 years. After 4 severe episodes, she started valacyclovir prophylaxis for 17 years. At age 49 years, she suffered from a severe S aureus infection and rIFN-γ treatment was started. Six weeks later, she stopped valacyclovir prophylaxis, and she remained infection-free since. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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