1. Volume 72, Issue 9, Pages 1073-1080 (November 2007)
Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia 
M.J. Tracz, J.P. Juncos, A.J. Croatt, A.W. Ackerman, J.P. Grande, K.L. Knutson, G.C. Kane, A. Terzic, M.D. Griffin, K.A. Nath 
Kidney International 
Volume 72, Issue 9, Pages (November 2007)
DOI: /sj.ki
Copyright © 2007 International Society of Nephrology Terms and Conditions

2. Figure 1
Renal hemodynamics in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). The data demonstrate the following hemodynamic parameters: glomerular filtration rate (GFR), renal blood flow (RBF), renal vascular resistance (RVR), and filtration fraction (FF). n=4 in each of the HO-1+/+ and HO-1−/− groups subjected to sham ischemia; n=6 and n=8 (GFR), and n=5 and n=7 (RBF, RVR, and FF) in HO-1+/+ and HO-1−/− groups subjected to IR respectively. *P<0.05 versus HO-1+/+ mice subjected to the same condition.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

3. Figure 2
Cardiac function in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). The data demonstrate the following: heart rate (beats per minute), circumferential shortening velocity (circumferences/s), fractional shortening (%), and cardiac output (ml/min/30 g). n=5 in each of the HO-1+/+ Sham and HO-1+/+ IR groups, and n=6 in each of HO-1−/− Sham and HO-1−/− IR groups.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

4. Figure 3
HO-1 expression in the kidney 4 h after sham or IR injury. Upper panel: Western analysis for HO-1 protein expression in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). Each lane represents protein extracted from a single kidney of an individual mouse. Equivalency of protein loading was verified by Ponceau staining (not shown). Lower panel: HO-1 mRNA by quantitative real-time reverse transcriptase-PCR in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). n=4 in each of the HO-1+/+ Sham and HO-1−/− Sham groups, and n=6 and n=8 in HO-1+/+ IR and HO-1−/− IR groups respectively.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

5. Figure 4
IL-6 mRNA determination by quantitative real-time reverse transcriptase-PCR in the kidney in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). n=4 and n=5 in the HO-1+/+ Sham and HO-1−/− Sham groups respectively, and n=8 and n=7 in the HO-1+/+ IR and HO-1−/− IR groups respectively. *P<0.05 versus HO-1+/+ mice subjected to the same condition.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

6. Figure 5
Western analysis for pSTAT3 and STAT3 expression in the kidney in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). Each lane represents protein extracted from a single kidney of an individual mouse, and equivalency of protein loading was verified by immunoblotting for β-actin.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

7. Figure 6
Serum levels of IL-6 in HO-1+/+ and HO-1−/− mice subjected to ischemia– reperfusion injury (IR) or sham ischemia (Sham). n=4 and n=5 in the HO-1+/+ Sham and HO-1−/− Sham groups respectively, and n=8 and n=7 in the HO-1+/+ IR and HO-1−/− IR groups respectively. *P<0.05 versus HO-1+/+ mice subjected to the same condition.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

8. Figure 7
Serum levels of IL-12 (p40) in HO-1+/+ and HO-1−/− mice subjected to ischemia– reperfusion injury (IR) or sham ischemia (Sham). n=4 and n=5 in the HO-1+/+ Sham and HO-1−/− Sham groups respectively, and n=8 and n=7 in the HO-1+/+ IR and HO-1−/− IR groups respectively. *P<0.05 versus HO-1+/+ mice subjected to the same condition.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

9. Figure 8
Serum levels of IL-5 and macrophage inflammatory protein (MIP)-1α in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). n=4 and n=5 in the HO-1+/+ Sham and HO-1−/− Sham groups respectively, and n=8 and n=7 in the HO-1+/+ IR and HO-1−/− IR groups respectively. *P<0.05 versus HO-1+/+ mice subjected to the same condition.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

10. Figure 9
IL-6 mRNA determination by quantitative real-time reverse transcriptase-PCR in the heart and lung in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). For studies in either organ, n=4 and n=5 in the HO-1+/+ Sham and HO-1−/− Sham groups respectively, and n=8 and n=7 in the HO-1+/+ IR and HO-1−/− IR groups respectively. *P<0.05 versus HO-1+/+ mice subjected to the same condition.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

11. Figure 10
Western analysis for pSTAT3 and STAT3 expression in the lung in HO-1+/+ and HO-1−/− mice subjected to ischemia–reperfusion injury (IR) or sham ischemia (Sham). Each lane represents protein extracted from a single lung of an individual mouse, and equivalency of protein loading was verified by immunoblotting for β-actin.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions