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C-MET/Phospho-MET Protein Expression and MET Gene Copy Number in Non-small Cell Lung Carcinomas  Koji Tsuta, MD, PhD, Yoshiki Kozu, MD, PhD, Takahiro.

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Presentation on theme: "C-MET/Phospho-MET Protein Expression and MET Gene Copy Number in Non-small Cell Lung Carcinomas  Koji Tsuta, MD, PhD, Yoshiki Kozu, MD, PhD, Takahiro."— Presentation transcript:

1 c-MET/Phospho-MET Protein Expression and MET Gene Copy Number in Non-small Cell Lung Carcinomas 
Koji Tsuta, MD, PhD, Yoshiki Kozu, MD, PhD, Takahiro Mimae, MD, Akihiko Yoshida, MD, Takashi Kohno, PhD, Ikuo Sekine, MD, PhD, Tomohide Tamura, MD, PhD, Hisao Asamura, MD, PhD, Koh Furuta, MD, PhD, Hitoshi Tsuda, MD, PhD  Journal of Thoracic Oncology  Volume 7, Issue 2, Pages (February 2012) DOI: /JTO.0b013e f Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Representative images of a c-MET- and phospho-MET-positive case of adenocarcinoma. A, Positive staining of c-MET with brown-stained membranes and cytoplasm (original magnification, ×200). B, Positive staining of phospho-MET with brown-stained membranes (original magnification, ×200). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e f) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Representative image of a bright-field in situ hybridization (BISH)-positive case of sarcomatoid carcinoma. Amplified MET gene signals appear as clusters of black dots and two to four CEN7 signals as red dots in the nuclei (original magnification, ×400). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e f) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Overall survival (OS) analysis. A, OS curves for patients with c-MET-negative (solid line) and c-MET-positive (dashed line) non-small cell lung carcinomas (NSCLCs) (p=0.189). B, OS curves for patients with c-MET-negative (solid line) and c-MET-positive (dashed line) nonsquamous NSCLCs (p=0.684). C, OS curves for patients with phospho-MET-negative (solid line) and phospho-MET-positive (dashed line) NSCLCs (p=0.547). D, OS curves for patients with phospho-MET-negative (solid line) and phospho-MET-positive (dashed line) nonsquamous NSCLCs (p=0.825). E, OS curves for patients with MET BISH-negative (solid line) and MET BISH-positive (dashed line) NSCLCs (p=0.135). F, OS curves for patients with MET BISH-negative (solid line) and MET BISH-positive (dashed line) nonsquamous NSCLCs (p=0.019). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e f) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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