1. Investigating the effects of long-term dornase alfa use on lung function using registry data 
Newsome S.J. , Daniel R.M. , Carr S.B. , Bilton D. , Keogh R.H.  
Journal of Cystic Fibrosis 
Volume 18, Issue 1, Pages (January 2019)
DOI: /j.jcf
Copyright © 2018 The Authors Terms and Conditions

2. Fig. 1 Flowchart of people included in analysis.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2018 The Authors Terms and Conditions

3. Fig. 2
Estimated mean difference in the change in ppFEV1 between dornase alfa users compared to non-users (dashed grey line), by years of treatment. The top-left figure shows the estimated overall average population effect, with the remaining figures highlighting the differential effects based on ppFEV1 at treatment initiation. The horizontal dashed grey line is the line indicating no treatment effect.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2018 The Authors Terms and Conditions

4. Fig. 3
Examples of possible lung function trajectories depending on treatment effect through time.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2018 The Authors Terms and Conditions