1. ECM changes between 3 and 12 months post-ltx in patients with or without BOS in the different pulmonary compartments.
ECM changes between 3 and 12 months post-ltx in patients with or without BOS in the different pulmonary compartments. Changes in total alveolar collagen, alveolar col IV and small airway biglycan between 3 and 12 months post-ltx in patients developing BOS (A, B, C) and patients without BOS (A’, B’, C’) on the group level. Difference in total alveolar collagen (A’’), alveolar col IV (B’’) and small airway biglycan (C’’) for each individual patient between 3 and 12 months post-ltx. Scatter dot plots are shown with median values. Statistical tests were Wilcoxon matched-pairs test in A, A’, B, B’ and Mann-Whitney test in A’’, B’’, C–C’’. BOS, bronchiolitis obliterans syndrome; col IV, collagen type IV; ECM, extracellular matrix; ltx, lung transplantation.
Catharina Müller et al. BMJ Open Resp Res 2017;4:e000177
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