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Novel Small-Caliber Vascular Grafts With Trimeric Peptide for Acceleration of Endothelialization  Fumiaki Kuwabara, MD, Yuji Narita, MD, PhD, Aika Yamawaki-Ogata,

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Presentation on theme: "Novel Small-Caliber Vascular Grafts With Trimeric Peptide for Acceleration of Endothelialization  Fumiaki Kuwabara, MD, Yuji Narita, MD, PhD, Aika Yamawaki-Ogata,"— Presentation transcript:

1 Novel Small-Caliber Vascular Grafts With Trimeric Peptide for Acceleration of Endothelialization 
Fumiaki Kuwabara, MD, Yuji Narita, MD, PhD, Aika Yamawaki-Ogata, MS, Kei Kanie, PhD, Ryuji Kato, PhD, Makoto Satake, PhD, Hiroaki Kaneko, PhD, Hideki Oshima, MD, PhD, Akihiko Usui, MD, PhD, Yuichi Ueda, MD, PhD  The Annals of Thoracic Surgery  Volume 93, Issue 1, Pages (January 2012) DOI: /j.athoracsur Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 (A) Gross view of scaffold. (B) Operative view of implantation (arrows denote the site of anastomosis). Luminal surface in (C) group CAG and (D) group C. (Scale bars: A, and B = 1 mm, C and D = 3 μm.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Immunofluorescence for von Willebrand factor (vWF) in group CAG at (A) 1 week, (B) 2 weeks, and (C) 6 weeks after implantation and in group C at (D) 1 week, (E) 2 weeks, and (F) 6 weeks. (Scale bar = 200 μm) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Results of ratio of endothelialization (* = p < 0.05).
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Scanning electron microscopy at (A) 1 week, (B) 2 weeks, and (C) 6 weeks after implantation in group CAG and (D) 1 week, (E) 2 weeks, and (F) 6 weeks in group C. (Scale bar = 60 μm.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 (A) Western blot analysis of the grafts with and without CAG peptide obtained 1 (1W), 2 (2W), and 6 weeks (6W) after implantation for endothelial nitrous oxide synthase (eNOS), thrombomodulin (TM), and β-actin was used as an internal standard of the Western blot. (B) Intensity of eNOS, which was standardized to that of β-actin, showed a significant difference between group CAG and group C about 1 week after implantation (n = 4; * = p < 0.05). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Immunofluorescence for α-smooth muscle actin (A) 1 week, (B) 2 weeks, and (C) 6 weeks after implantation in group CAG and (D) 1 week, (E) 2 weeks, and (F) 6 weeks in group C. (Scale bar = 200 μm) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

8 Fig 7 (A) The results of Western blot analysis of the grafts with and without CAG peptide retrieved 6 weeks after implantation for α-smooth muscle actin (ASMA), calponin, and β-actin were used as an internal standard of Western blotting. (B) Results of the intensity of ASMA and calponin, which was standardized to that of β-actin (n = 4; * = p < 0.05). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

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