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Allergenic significance of cephalosporin side chains

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Presentation on theme: "Allergenic significance of cephalosporin side chains"— Presentation transcript:

1 Allergenic significance of cephalosporin side chains
Brian A. Baldo, PhD, Nghia H. Pham, PhD  Journal of Allergy and Clinical Immunology  Volume 136, Issue 5, Pages (November 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 General structure of cephalosporins and structures of cephalosporins used in the study1 showing the R1 methoxyimino group (magenta) and the R2 ester and thioether groups (blue and red, respectively). Space-filling models show that, compared with cefodizime, the thioether group of ceftriaxone is at least partially hindered by the adjacent ring N-methyl group, perhaps impeding IgE binding. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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