1. PTA for AUC/MIC ratio ≥800 for each 48-hour AUC: AUC0 to 48 (A), AUC48 to 96 (B), and AUC96 to 144 (C).
PTA for AUC/MIC ratio ≥800 for each 48-hour AUC: AUC0 to 48 (A), AUC48 to 96 (B), and AUC96 to 144 (C). MICs ranged from 0.5 to 2.0 μg/ml. The four vancomycin dosing regimens were 15-mg/kg LD followed by 7.5-mg/kg MD (○); 15-mg/kg LD followed by 15-mg/kg MDs (□); 20-mg/kg LD followed by 7.5-mg/kg MDs (△); and 20-mg/kg LD followed by 10-mg/kg MDs (♢).
Brian S. Decker et al. CJASN 2010;5:
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