1. Volume 41, Issue 6, Pages 983-991 (December 2004)
Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis 
Jennifer A. Eleazar, Lorenzo Memeo, Jeffrey S. Jhang, Mahesh M. Mansukhani, Steven Chin, Soo Mi Park, Jay H. Lefkowitch, Govind Bhagat 
Journal of Hepatology 
Volume 41, Issue 6, Pages (December 2004)
DOI: /j.jhep
Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

2. Fig. 1
CK7+cell types seen with examples of the semi-quantitative scoring system. (a) Collapsed ductular structure at the edge of a portal tract containing a lymphoid aggregate (score 1+); (b) irregular, circumferential ductules with vague or inapparent lumens (score 3+); (c) small, ovoid IPCs and cell doublets (arrows), (score 1+); (d) increased number of IPCs, with some forming clusters, arrows (score 3+); (e) IHBC (arrow) in close approximation with less intensely stained CK7+hepatocytes (arrowheads) (score 1+); (f) clusters of CK7+hepatocytes (arrowheads) with membranous and faint cytoplasmic staining in association with IHBCs (arrows) (score 3+).
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

3. Fig. 2
Comparison of CK7 to CK19 staining for each of the cell types studied.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

4. Fig. 3
Distribution of CK7+cell types and semi-quantitative scores according to grade and stage of disease.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

5. Fig. 4
CK7/MIB-1 double staining to determine proliferation indices. (a) Irregular CK7+ductular structures with MIB-1+nuclei (arrows); (b) MIB-1/CK7 double positive IHBC (arrow) adjacent to CK7+progenitor cells; (c) CK7+/MIB-1-IHBCs (arrowheads) adjacent to proliferating MIB-1+native (CK7−) hepatocytes (arrows); (d) non-proliferating CK7+hepatocytes.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

6. Fig. 5
Schematic representation of periportal cell types with CK7/CK19 immunostaining in chronic hepatitis. At top: diagrammatic representations of the various CK7/CK19+cell types and structures. Actual photomicrographs of these constituents are shown below. The dashed arrows suggest potential pathways by which activated progenitor cells in the vicinity of canals of Hering give rise to various CK7/CK19+elements (see Section 4). The portal tract structures at upper left include PV (portal vein), A (hepatic artery branch), BD (bile duct). CV at right=central vein.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2004 European Association for the Study of the Liver Terms and Conditions