1. Hormones, Blood, and Immunity
Created by Educational Technology Network

2. Endocrine Organs
Virtual Rats
Hormones
Blood
Blood Typing Lab 10 20 30 40 50

3. Question
The endocrine system has the same function as the ______________ system.

4. Answer 1 – 10
Nervous system

5. Question
How can you tell a target organ from a nontarget organ given a certain hormone?

6. Answer 1 – 20
A target organ will have a receptor for the hormone, while a nontarget organ will not

7. Question
Compare the locations of the receptors for a steroid and nonsteroid hormone on a target cell.

8. Answer 1 – 30 Steroid Hormone Nonsteroid hormone
Receptor would be found inside the cell
Receptor would be found on the outside of the cell

9. Question
What is negative feedback?

10. Answer 1 – 40
Negative feedback is when hormone secretion inhibits further hormone release

11. Question
Draw a picture of speedoman and show me where the following are located:
Hypothalamus
Pituitary
Thyroid
Adrenal gland
Testes

12. Answer 1 – 50

13. Question
Why would an organ increase or decrease in size, typically?

14. Answer 2 – 10 Increase in size = hypertrophy
This would occur if the organ is very activated
Decrease in size = atrophy
This would occur if the organ is inhibited
The thymus gland is an exception. It is a target for cortisol and, when it is in a hypercortisolic environment, it shrinks!

15. Question 2 - 20 Draw all 3 pathways for the production of:
Thyroid hormone (T3/T4)
Cortisol
Testosterone

16. Answer 2 – 20

17. Question 2 - 30 Give the identity of the hormone: Organ
Effect of Hormone Added
Hypothalamus
Decrease
Pituitary
Increase
Adrenal Gland NC
Thymus
Thyroid
Testicles
Prostate/Seminal Vesicles
Body Weight

18. Answer 2 – 30
TRH

19. Question
What would my data table look like if I injected extra cortisol into the rat?
Organ
Effect of Hormone Added
Hypothalamus ?
Pituitary
Adrenal Gland
Thymus
Thyroid
Testicles
Prostate/Seminal Vesicles
Body Weight

20. Answer 2 – 40 Organ Effect of Hormone Added Reason Hypothalamus
Decrease in size
Cortisol exhibits negative feedback and would repress hypo activity
Pituitary
Same as above
Adrenal Gland
Negative feedback; the gland is not being activated like it should so it shrinks
Thymus
Cortisol represses the immune system and the thymus is an immune organ. Thymus would get “lazy” and would shrink
Thyroid
No change
This organ has nothing to do with cortisol
Testicles
Prostate/Seminal Vesicles
Body Weight
Symptom of hypercortisolism = weight loss

21. Question 2 - 50 Identify the injected hormone Organ
Effect of Hormone Added
Hypothalamus
Decrease in size
Pituitary
Adrenal Gland
No change
Thymus
Thyroid
Testicles
Increase in size
Prostate/Seminal Vesicles
Body Weight

22. Answer 2 – 50 LH

23. Question
When the hypothalamus releases ____________________, it stimulates the pituitary to release growth hormone

24. Answer 3 – 10
GHRH (growth hormone releasing hormone)

25. Question
When the hypothalamus releases ____________, the anterior pituitary releases thyroid stimulating hormone.

26. Answer 3 – 20
TRH or thyroid releasing hormone

27. Question
Draw me a picture of the cortisol production pathway starting at the hypothalamus.

28. Answer 3 – 30

29. Question
What disease results from too much thyroid hormone? Give me both.

30. Answer 3 – 40
Graves disease and hyperthyroidism

31. Question
What are the symptoms of too much testosterone?

32. Answer 3 – 50
Increased muscle mass
Baldness
Acne

33. Question
Draw me a picture of a vial of blood before AND after it has gone through a centrifuge. Label the parts

34. Answer 4 – 10

35. Question
Give me all the names that mean the same as WBC

36. Answer 4 – 20
WBC = white blood cell = leukocyte

37. Question
What does it mean to be anemic? There are 2 possible causes….

38. Answer 4 – 30 Anemia is caused by Too little RBCs
Too little hemoglobin

39. Question
Draw me a picture of a RBC that is type AB-

40. Answer 4 – 40
Your blood cell should have circles and triangles on the outside

41. Question
Give me all the blood types that would have anti-Rh antibodies

42. Answer 4 – 50
A-, AB-, B-, O-
All of them aren’t used to seeing Rh antigens (crosses) on the RBCs

43. Question
What would happen if you were to mix type A blood with anti-B serum?

44. Answer 5 – 10
Nothing would happen! The serum is looking for B antigens (triangles) and RBCs that are type A do not have B antigens on their surfaces

45. Question 5 - 20 What is Timmy’s blood type?
Anti-D is the same thing as saying anti-Rh

46. Answer 5 – 20 O+

47. Question
If you were to have AB- blood, what would you expect to see after adding
1. Anti A serum
2. anti B serum
3. Anti Rh serum

48. Answer 5 – 30 Anti A  agglutination Anti B  agglutination
Anti Rh  no reaction/change

49. Question
Your BFF is O+ blood type. What antibodies does she have floating around in her blood stream? What antigens are found on her cells?

50. Answer 5 – 40
Antigen: Rh (crosses)
Antibodies: anti-A, anti-B

51. Question 5 - 50 What blood type is the universal donor?
What blood type is the universal recipient?

52. Answer 5 – 50
Donor = O-
Recipient = AB+