1. C4A: A schizophrenia gene
I think the white letters with black outline stands out a lot better than the tan color. I think the title is fine, but there might be something more catchy you could come up with!
Soroush Besharat

2. What is schizophrenia?
I really like the colors in this slide! Black background really makes them pop

3. What is synaptic pruning?

4. Where is C4A mutated in schizophrenia?x
A2M comp
NTR-C
A2M-N2
A2M recep
A2M-N
ANATO
A2M Thiol-ester

5. How well-conserved is C4A?
A2M
A2M comp
A2M recep
NTR-C
Human (1744 AA)
A2M-N2
A2M-N
ANATO
A2M Thiol-ester
Chimp (1744 AA)
99% iden.
Mouse (1735 AA)
73% iden.
Zebrafish (1717 AA)
34% iden
I was just playing around with colors, but I think that having colors that are very different from each other helps differentiate between the different domains (since there are so many). I picked these bright colors to kind of tie in the bright images that you started out with, since they really stood out to me. I also added shading to the text inside the domain, and I made the strand skinner to make the domains stand out more too. I also made your title and label text bigger. It’s not necessary to have the domain names in all of the ones after human since the colors are the same and the domains don’t change between organisms.
Frog (1683 AA)
41% iden.

6. Phylogeny Mouse Rat Rhesus macaque Gorilla Human Chimpanzee Dog Cat
Cow
Pig
Need bigger names of animals!!!!
Fly
Chicken
Zebrafish
Frog

7. Gene ontology
Biological process Inflammatory response Complement activation Molecular function Endopeptidase inhibitor activity Protein binding Cellular component Extracellular region Extracellular space
I would add an image here later on if you find a good one, but I like the color change!

8. Primary goal: Discover how C4A regulates synaptic pruning
Aim 1: Identify pruning domains
Aim 2: Identify small molecules
Add animations
Aim 3:

9. Primary goal: Discover how C4A regulates synaptic pruning?

10. http://journal. frontiersin. org/article/10. 3389/fnana. 2014

11. Aim 1: Identify pruning domains

12. Aim 1: Identify pruning domains

13. Aim 1: Identify pruning domains
behavioral assays relating to learning and memory, locomotion and impaired sensory motor gating
Leung et al. 2013

14. Aim 2: Identify small molecules
Change this image to reflect the

15. Aim 2: Identify small molecules
Edit this image to reflect the screen being done