1. Nutrigenomics
KNH 413

3. Nutrigenomics and Disease
Cancer
Use of omega-3 & EPA for rare types
Predicting benefit difficult in other types
Responders and non-responders
Colon cancer
Folate intake and alcohol
Fruits and vegetables
Breast cancer
Antioxidants

4. Nutrigenomics and Disease
Obesity
Susceptibility with conducive environment
Polygenic trait
Promising research
Perilipin
Serotonin receptor gene promoter

5. Nutrigenomics and Disease
Thrifty Gene hypothesis
Metabolic status and fetal adaptation predict disease in adulthood
Proneness to metabolic syndrome, obesity, diabetes, CVD

6. Nutrigenomics and Disease
Diabetes
Focus on type 2
Metabolic syndrome, insulin resistance
GLUT 2
PPARy
APOE

7. Nutrigenomics and Disease
Cardiovascular Disease
Dyslipidemias
Familial hypercholesterolemia
PUFAs on HDL
Omega-3s and TG
Omega-6s and inflammation

8. Dietetics and Genetics
Understanding nutrient interactions and genes
Future of diet counseling
Beware of home testing kits
“DNA diet”
Sciona
Costly
EGAPP Project
To establish a coordinated process