1. Nutrigenomics
KNH 413

3. Nutrigenomics and Disease
Cancer
Use of omega-3 & EPA for rare types
Predicting benefit difficult in other types
Responders and non-responders
Colon cancer
Folate intake and alcohol
Fruits and vegetables
Breast cancer
Antioxidants
Prevention and treatment:
ovarian: predisposing factors: obesity, high BMI, celenium has positive role in prevention
Brazilian Nuts
increase phytochemicals
eating whole grains
Pancreatic cancer: diabetes increases risk
diet high in red meat
prescribe lean meat diet
plenty of fruits and veggies
High fiber, omega 3, alcohol in moderation,
Talking to younger generations for prevention of disease
How do you get them to follow your suggestions
show what could happen
health belief model

4. Nutrigenomics and Disease
Obesity
Susceptibility with conducive environment
Polygenic trait
Promising research
Perilipin
Serotonin receptor gene promoter

5. Nutrigenomics and Disease
Thrifty Gene hypothesis
Metabolic status and fetal adaptation predict disease in adulthood
Proneness to metabolic syndrome, obesity, diabetes, CVD

6. Nutrigenomics and Disease
Diabetes
Focus on type 2
Metabolic syndrome, insulin resistance
GLUT 2
PPARy
APOE
Prevention: breast feeding
vitamin B suplementation
height weight
glut 2
ppary
APOE
clinical genomics
overexpression of some genes
difficult to do because of great variables and environmental

7. Nutrigenomics and Disease
Cardiovascular Disease
Dyslipidemias
Familial hypercholesterolemia
PUFAs on HDL
Omega-3s and TG
Omega-6s and inflammation
Controle diet early on
watch sodium, processed food, fat intake
Early prevention
Not as manegable as diabetes

8. Dietetics and Genetics
Understanding nutrient interactions and genes
Future of diet counseling
Beware of home testing kits
“DNA diet”
Sciona
Costly
EGAPP Project
To establish a coordinated process
Future diet counseling with testing kits- very costly; give a DNA diet, get a generic diet “eat healthy, get exercise 3xs a week” CDC is cracking down on it
EGAPP: evaluation of Genomic Application Practice and Prevention